MeSH on demand — työkalu sopivien asiasanojen löytämiseksi

MeSH on Demandin avulla on helppo löytää tietyn aiheen MeSH-termejä. MeSH on Demand -hakuun voi lisätä (kopioida) jopa 10000 merkkiä tekstiä, jonka ei tarvitse olla hakusanoja, vaan mitä tahansa tekstiä, vaikka artikkelin abstrakti.

Esimerkiksi artikkelin

Jääskeläinen P, Heliö T, Aalto-Setälä K, Kaartinen M, Ilveskoski E, Hämäläinen L, Melin J, Kärkkäinen S, Peuhkurinen K, Nieminen MS, Laakso M; the Finhcm Study Group, Kuusisto J. A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy. Ann Med. 2014 Jun 3:1-6.

abstraktista (joka siis kopioidaan ja liitetään hakuruutuun)

Background. In the nationwide FinHCM Study including 306 Finnish patients with hypertrophic cardiomyopathy (HCM), we have previously identified two founder mutations in the alpha-tropomyosin (TPM1-D175N) and myosin-binding protein C (MYBPC3-Q1061X) genes, accounting for 18% of all cases. Objective. To screen additional mutations, previously identified in eastern Finnish cohorts with HCM, in the FinHCM Study population. Patients and methods. Ten mutations in the beta-myosin heavy chain gene (MYH7), TPM1, and MYBPC3 were screened. Results. MYH7-R1053Q was found in 17 of 306 patients (5.6%). No carriers of MYH7-R719W or N696S were found. A novel TPM1-D175G mutation was found in a single patient. MYBPC3 mutations were found in 14 patients: IVS5-2A-C in two, IVS14-13G-A in two, K811del in six, and A851insT in four patients. Altogether, a HCM-causing mutation was identified in 32 patients, accounting for 10.5% of all cases. In addition, two MYBPC3 variants R326Q and V896M with uncertain pathogenicity were found in eight and in 10 patients, respectively. Conclusion. Combining the present findings with our previous results, a causative mutation was identified in 28% of the FinHCM cohort. MYH7-R1053Q was the third most common mutation, and should be screened in all new cases of HCM in Finland.

MeSH on Demand -työkalu poimii MeSH-termeiksi nämä:

    • Cardiomyopathy, Hypertrophic
    • Carrier Proteins
    • Female
    • Finland
    • Heterozygote
    • Humans
    • Male
    • Mutation
    • Myosin Heavy Chains
    • Tropomyosin
    • Ventricular Myosins
    • Virulence

Katso kuvat NML:n ohjeesta ja kokeile!

  • Ai, mitä niillä MeSH-termeillä sitten tehdään? Ne ovat asiasanoja, joita käytetään sisällönkuvailuun (indeksointiin) lääketieteen tietokannoissa, kuten MEDLINE ja MEDIC. Käyttämällä asiasanoja hakusanoina, voi saada täsmällisempiä, osuvampia tuloksia kuin omin, vapain sanoin. Katso video!

 

Tuulevi Ovaska, palvelupäällikkö (tietoasiantuntija)

Mainokset

Frequently asked questions 1 – What is the difference between MEDLINE and PubMed?

Question:

  • What is the difference between MEDLINE and PubMed?

There is a fact sheet of NLM (National Library of Medicine, USA) called MEDLINE, PubMed, and PMC (PubMed Central): How are they different?  that explains the difference in detail.

Shortly:

MEDLINE is the National Library of Medicine (NLM) journal citation database.

MEDLINE database is searchable from NLM as a subset of the PubMed database but also other search services that license the data.

PubMed includes MEDLINE plus the following types of citations:

  • in-process citations (records for articles before quality control and indexing)
  • citations to articles that are out-of-scope ahead of print citations (preceding article’s final publication)
  • pre-1966 citations that have not yet been updated with current MeSH (Medical Subject Headings)
  • citations to some additional life sciences journals that submit full text to PubMed Central and receive a qualitative review by NLM
  • citations to manuscripts of articles published by NIH-funded researchers
  • citations for the majority of books available on the NCBI Bookshelf

If you want to search only MEDLINE in PubMed, use the Journal Categories filter MEDLINE.

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By: Tuulevi Ovaska, Head of Services, Kuopio University Hospital Medical Library, University of Eastern Finland Library